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KMID : 1161420150180091032
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Journal of Medicinal Food
2015 Volume.18 No. 9 p.1032 ~ p.1041
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Fucoidan Prevents the Progression of Osteoarthritis in Rats
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Lee Don-Gil
Park Sang-Yong
Chung Won-Seok
Park Jae-Hee
Hwang Eun-Son
Mavlonov Gafurjon Tom
Kim In-Ho
Kim Ki-Young
Yi Tae-Hoo
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Abstract
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This study investigated the effects of fucoidan (extract from Hizikia fusiforme) on symptoms and inflammatory cytokine activation in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Forty male SD rats were divided into five groups, including normal, negative control (MIA), positive control (Lyprinol), and two experimental groups treated with 50 or 100?mg/kg fucoidan. Weight-bearing assessments were done after MIA injection into the right knee to induce OA. After 14 days of treatment, microcomputed tomographic (micro-CT) images were made of rat knee joints, and then animals were sacrificed for joint histology and inflammatory cytokine level assessments. MIA injection successfully induced OA by causing 40% weight-bearing imbalance, severe bone loss and cartilage degeneration, and markedly increased cytokine levels. However, fucoidan groups showed over 45% of imbalance and no articular cartilage surface lesions or change in subchondral trabecular bones in Micro-CT images. Histological analysis revealed that cartilage morphology and cell counts were also normal in the 100?mg/kg fucoidan group. In addition, the 100?mg/kg fucoidan groups exhibited lower serum tumor necrosis factor alpha (TNF-α) (30%), interleukin 1 beta (IL-1β) (48%), and matrix metalloproteinase-1 (MMP-1) (65%) compared to the MIA groups. These results suggest that administration of fucoidan prevents the progression of OA in a MIA-induced OA rat model.
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KEYWORD
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health functional food, matrix metalloproteinases, MIA-induced rat, osteoarthritis, seaweeds
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